Rab12 Gene Summary [Rat]
Predicted to enable GDP binding activity and GTPase activity. Predicted to be involved in several processes, including endocytic recycling; endosome to lysosome transport; and positive regulation of macroautophagy. Predicted to act upstream of or within cellular response to type II interferon. Located in secretory granule. Orthologous to human RAB12 (RAB12, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab12 |
| Official Name | RAB12, member RAS oncogene family [Source:RGD Symbol;Acc:3527] |
| Ensembl ID | ENSRNOG00000019295 |
| Bio databases IDs | |
| Aliases | RAB12, member RAS oncogene family |
| Synonyms | 2900054P15Rik, AK054427, LOC100362985, LOC105371977, RAB12, member RAS oncogene family |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rab12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- 50S ribosome-binding GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Elongation factor Tu GTP binding domain
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic scoliosis
role in cell
- phosphorylation in
- elongation
- proliferation
- transport
- autophagy by
- response by
- macroautophagy in
- ciliogenesis in
- degranulation in
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular nanovesicle
- lysosome
- Golgi Apparatus
- cytosol
- endosomal membrane
- autophagic vacuoles
- secretory granules
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rab12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein catabolic process
- autophagy
- Rab protein signal transduction
- endosome to lysosome transport
- exocytosis
- protein secretion
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- endosome
- synaptic vesicle
- trans-Golgi network transport vesicle
- cytosol
- Golgi membrane
- recycling endosome membrane
- autophagic vacuole
- plasma membrane
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GDP binding