Higd1a Gene Summary [Rat]
Predicted to be involved in mitochondrial respirasome assembly and negative regulation of apoptotic process. Predicted to act upstream of or within several processes, including cellular response to glucose starvation; negative regulation of release of cytochrome c from mitochondria; and positive regulation of protein serine/threonine kinase activity. Predicted to be located in mitochondrial inner membrane and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrion. Orthologous to human HIGD1A (HIG1 hypoxia inducible domain family member 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Higd1a |
| Official Name | HIG1 hypoxia inducible domain family, member 1A [Source:RGD Symbol;Acc:620215] |
| Ensembl ID | ENSRNOG00000019428 |
| Bio databases IDs | |
| Aliases | HIG1 hypoxia inducible domain family, member 1A |
| Synonyms | 2210020B17Rik, 7420700H20Rik, HIG1, HIG1 domain family, member 1A, HIG1 hypoxia inducible domain family member 1A, HIG1 hypoxia inducible domain family, member 1A, HIMP1, Hypoxia-induced gene 1, RCF1a |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Higd1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hypoxia induced protein conserved region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- Parkinson disease
- colon cancer
role in cell
- activation in
- ubiquitination in
- apoptosis
- accumulation in
- response by
- dysfunction
- dysfunction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cellular membrane
- Nucleus
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Higd1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- mitochondrial respiratory chain supercomplex assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- macromolecular complex
- mitochondrial inner membrane
- respiratory chain
- nucleoplasm