Ptprn Gene Summary [Rat]
Enables GTPase binding activity. Involved in several processes, including positive regulation of type B pancreatic cell proliferation; response to estrogen; and response to insulin. Located in several cellular components, including axon terminus; cytoplasmic vesicle; and neuronal cell body. Is active in neuronal dense core vesicle membrane. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human PTPRN (protein tyrosine phosphatase receptor type N). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptprn |
| Official Name | protein tyrosine phosphatase, receptor type, N [Source:RGD Symbol;Acc:620777] |
| Ensembl ID | ENSRNOG00000019587 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, receptor type, N |
| Synonyms | BEM-3, IA-2, IA-2/PTP, ICA105, ICA512, mIA-A, mKIAA4064, protein tyrosine phosphatase receptor type N, protein tyrosine phosphatase, receptor type, N, PTP IA-2, PTPLP, R-PTP-N |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ptprn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-tyrosine-phoshatase
- catalytic domain
- pseudo protein tyrosine phosphatase domain
- spectrin binding
- enzyme binding
- Protein tyrosine phosphatase, catalytic domain
- central domain
- transcription factor binding
- PTP_DSP_cys
- protein binding
- Protein-tyrosine phosphatase receptor IA-2
- phosphatase domain
- Protein tyrosine phosphatase, catalytic domain motif
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- PEST domain
- Protein-tyrosine phosphatase
- beta2 syntrophin binding domain
- cytoplasmic domain
- transmembrane domain
- phosphatase
- membrane-proximal domain
- cytosolic tail domain
- RESP18 domain
Pathways
Biological processes and signaling networks where the Ptprn gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- seizures
- insulitis
- pharmacologically induced seizure
- hyperplasia
role in cell
- survival
- proliferation
- quantity
- replication in
- activation
- response
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear region
- cellular membrane
- Nucleus
- endosomes
- Golgi Apparatus
- secretory granule membrane
- synapse
- dense-core vesicles
- secretory granules
- perikaryon
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ptprn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- luteinization
- regulation of secretion
- insulin secretion involved in cellular response to glucose stimulus
- insulin secretion
- response to reactive oxygen species
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transport vesicle membrane
- endosome
- synaptic vesicle
- secretory granule
- Golgi apparatus
- synapse
- neuronal cell body
- perikaryon
- axon terminus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- spectrin binding
- protein tyrosine phosphatase activity
- transcription factor binding
- small conjugating protein ligase binding