Ttyh3 Gene Summary [Rat]
Predicted to enable calcium ion binding activity; intracellularly calcium-gated chloride channel activity; and volume-sensitive chloride channel activity. Predicted to be involved in L-glutamate transmembrane transport and chloride transport. Predicted to be part of chloride channel complex. Predicted to be active in plasma membrane. Orthologous to human TTYH3 (tweety family member 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ttyh3 |
| Official Name | tweety family member 3 [Source:RGD Symbol;Acc:1309549] |
| Ensembl ID | ENSRNOG00000055583 |
| Bio databases IDs | |
| Aliases | tweety family member 3 |
| Synonyms | 2900029G13RIK, mTTY3, TTY3, Ttyh3 predicted, tweety family member 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ttyh3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- volume-sensitive anion channel
- tweety N-terminal domain
- chloride channel
- intracellular calcium activated chloride channel
- calcium ion binding
- protein binding
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- schizophrenia
- organismal death
- diabetes mellitus
- cerebral amyloid angiopathy
role in cell
- apoptosis
- expression in
- phosphorylation in
- proliferation
- migration
- invasion by
- sphere formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ttyh3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transmembrane transport
- chloride transport
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- intracellular calcium activated chloride channel activity
- protein binding
- calcium ion binding
- volume-sensitive chloride channel activity
- chloride channel activity
- volume-sensitive anion channel activity