Jmjd8 Gene Summary [Rat]
Predicted to enable cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; positive regulation of sprouting angiogenesis; and regulation of pyruvate kinase activity. Predicted to act upstream of or within cellular respiration and sprouting angiogenesis. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in nucleus. Orthologous to human JMJD8 (jumonji domain containing 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Jmjd8 |
| Official Name | jumonji domain containing 8 [Source:RGD Symbol;Acc:1307381] |
| Ensembl ID | ENSRNOG00000019729 |
| Bio databases IDs | |
| Aliases | jumonji domain containing 8 |
| Synonyms | 2610003J06Rik, C16orf20, jumonji domain containing 8, PP14397, RGD1307381 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Jmjd8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- JmjC domain
- RmlC-like cupin superfamily
- Cupin-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- hepatocellular carcinoma
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- gastric adenocarcinoma
- gastric epithelial cancer
- testicular germ cell tumor
regulated by
role in cell
- phosphorylation in
- accumulation in
- glycolysis in
- interaction in
- respiration
- trimethylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Jmjd8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of glycolysis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- nucleus
- cytoplasm
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding