Cavin1 Gene Summary [Rat]
Predicted to enable identical protein binding activity and rRNA primary transcript binding activity. Predicted to be involved in DNA-templated transcription; positive regulation of cell motility; and protein secretion. Located in caveola. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 4. Orthologous to human CAVIN1 (caveolae associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cavin1 |
| Official Name | caveolae associated protein 1 [Source:RGD Symbol;Acc:1307685] |
| Ensembl ID | ENSRNOG00000019778 |
| Bio databases IDs | |
| Aliases | caveolae associated protein 1 |
| Synonyms | 2310075E07RIK, caveolae associated 1, caveolae associated protein 1, CAVIN, Cav-p60, CGL4, FKSG13, PTRF, TTF-I |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cavin1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- rRNA primary transcript binding
- transcription regulator
- PTRF/SDPR family
- coiled-coil domain
- protein binding
- basic domain
- identical protein binding
Pathways
Biological processes and signaling networks where the Cavin1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- coronary artery disease
- psoriasis
- urothelial bladder carcinoma
- transitional cell bladder cancer
- congenital generalized lipodystrophy type 4
- breast carcinoma
- inflammatory bowel disease
role in cell
- expression in
- phosphorylation in
- differentiation
- generation in
- assembly
- formation
- mobility
- mobilization in
- tyrosine phosphorylation in
- assembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- caveolae-derived endocytic vesicles
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- focal complexes
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- lipid droplets
- cytosol
- caveolae
- nucleoplasm
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cavin1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription initiation from RNA polymerase I promoter
- rRNA transcription
- termination of RNA polymerase I transcription
- protein secretion
- positive regulation of cell motility
Cellular Component
Where in the cell the gene product is active
- nucleus
- caveola
- cytoplasm
- intracellular membrane-bounded organelle
- mitochondrion
- membrane raft
- cytosol
- endoplasmic reticulum
- macromolecular complex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- RNA binding
- protein binding
- rRNA primary transcript binding