Mef2d Gene Summary [Rat]
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein dimerization activity. Involved in positive regulation of DNA-templated transcription. Located in nucleus. Orthologous to human MEF2D (myocyte enhancer factor 2D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mef2d |
| Official Name | myocyte enhancer factor 2D [Source:RGD Symbol;Acc:621489] |
| Ensembl ID | ENSRNOG00000031778 |
| Bio databases IDs | |
| Aliases | myocyte enhancer factor 2D |
| Synonyms | 2210408E11RIK, myocyte enhancer factor 2D |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mef2d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- MEF2 binding domain
- transcription regulator
- SRF-type transcription factor (DNA-binding and dimerization domain)
- DNA binding domain
- nucleic acid binding
- Holliday junction regulator protein family C-terminal repeat
- enzyme binding
- transcription factor binding
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- MADS
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- protein homodimerization
- transcription factor activity
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Mef2d gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Apelin Endothelial Signaling Pathway
- Calcium Signaling
- Calcium-induced T Lymphocyte Apoptosis
- Cardiac Hypertrophy Signaling
- Cellular Effects of Sildenafil (Viagra)
- Cholecystokinin/Gastrin-mediated Signaling
- Corticotropin Releasing Hormone Signaling
- ERK5 Signaling
- G-Protein Coupled Receptor Signaling
- Gα12/13 Signaling
- Nur77 Signaling in T Lymphocytes
- p38 MAPK Signaling
- Role of NFAT in Cardiac Hypertrophy
- Role of NFAT in Regulation of the Immune Response
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- pain
- Parkinson disease
- liver cancer
- metastasis
- headache
- liver neoplasia
- digestive system cancer
- abdominal cancer
- migraine without aura
role in cell
- expression in
- activation in
- phosphorylation in
- differentiation
- production in
- apoptosis
- number
- invasion by
- upregulation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- inner membrane
- Mitochondria
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mef2d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- skeletal muscle cell differentiation
- apoptotic process
- nervous system development
- osteoblast differentiation
- cell differentiation
- chondrocyte differentiation
- endochondral ossification
- positive regulation of transcription from RNA polymerase II promoter
- adult heart development
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein homodimerization activity
- histone deacetylase binding
- protein heterodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity