Pla2g4a Gene Summary [Rat]
Enables calcium-dependent phospholipase A2 activity and histone acetyltransferase binding activity. Involved in several processes, including cellular response to homocysteine; decidualization; and female gonad development. Located in perinuclear region of cytoplasm and zymogen granule. Used to study hyperglycemia. Biomarker of asthma; brain ischemia; papilloma; polycystic kidney disease; and transitional cell carcinoma. Orthologous to human PLA2G4A (phospholipase A2 group IVA). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pla2g4a |
| Official Name | phospholipase A2 group IVA [Source:RGD Symbol;Acc:67366] |
| Ensembl ID | ENSRNOG00000002657 |
| Bio databases IDs | |
| Aliases | phospholipase A2 group IVA |
| Synonyms | cPLA2, cPLA2-alpha, cPLA2-α, cytosolic phospholipase a2 α, GURDP, Ipla2beta, IVA-PLA2, LOC100911675, phospholipase A2 group 4A, phospholipase A2 group IVA, phospholipase A2, group IVA (cytosolic, calcium-dependent), Pla2c, PLA2G4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pla2g4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- sphingolipid binding
- lysophospholipase
- Lysophospholipase catalytic domain
- calcium-dependent phospholipase A2
- calcium ion binding
- calcium-dependent phospholipid binding
- calcium-independent phospholipase A2
- enzyme
- O-acyltransferase
- phosphatidylinositol binding
- phospholipase A2
- Patatins and Phospholipases
- Cytoplasmic phospholipase A2, catalytic subunit
- binding protein
- Protein kinase C conserved region 2 (CalB)
- histone acetyltransferase binding
- C2 domain
Pathways
Biological processes and signaling networks where the Pla2g4a gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Antioxidant Action of Vitamin C
- Atherosclerosis Signaling
- CCR3 Signaling in Eosinophils
- Docosahexaenoic Acid (DHA) Signaling
- Eicosanoid Signaling
- Endothelin-1 Signaling
- ERK/MAPK Signaling
- Fc Epsilon RI Signaling
- Glucocorticoid Receptor Signaling
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- Neuroinflammation Signaling Pathway
- p38 MAPK Signaling
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Serotonin Receptor Signaling
- Sperm Motility
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- renal fibrosis
- Crohn disease
- collagen-induced arthritis
- lung adenocarcinoma
- lung adenocarcinoma formation
- COVID-19
- myelodysplastic syndrome
- pelvic organ prolapse
- bleeding
role in cell
- proliferation
- expression in
- survival
- differentiation
- production in
- formation in
- apoptosis
- cell death
- degradation in
- killing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane vesicles
- caveolae fraction
- intracellular membrane-bounded organelle
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- lipid droplets
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- mitochondrial inner membrane
- nuclear envelope
- zymogen granules
- growth cone
- synaptosomes
- perikaryon
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pla2g4a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerol metabolic process
- positive regulation of platelet activation
- phosphatidylcholine acyl-chain remodeling
- icosanoid metabolic process
- monoacylglycerol biosynthetic process
- platelet activating factor biosynthetic process
- regulation of cell proliferation
- positive regulation of prostaglandin secretion
- leukotriene biosynthetic process
- phosphatidylcholine catabolic process
- arachidonic acid secretion
- glycerophospholipid catabolic process
- prostaglandin biosynthetic process
- positive regulation of macrophage activation
- positive regulation of T-helper 1 type immune response
- phosphatidylglycerol catabolic process
- establishment of localization in cell
- cellular response to antibiotic
- arachidonic acid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear envelope
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- endoplasmic reticulum
- Golgi apparatus
- Golgi membrane
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- phospholipase A2 activity
- lysophospholipase activity
- phosphatidylinositol-4-phosphate binding
- calcium-independent phospholipase A2 activity
- O-acyltransferase activity
- calcium-dependent phospholipase A2 activity
- calcium ion binding
- phosphatidylinositol-5-phosphate binding
- phosphatidylinositol-3-phosphate binding
- calcium-dependent phospholipid binding