Stxbp3 Gene Summary [Rat]
Enables syntaxin-1 binding activity. Predicted to be involved in several processes, including exocytosis; negative regulation of calcium ion-dependent exocytosis; and platelet aggregation. Predicted to act upstream of or within several processes, including cellular response to type II interferon; negative regulation of D-glucose import; and secretion by cell. Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human STXBP3 (syntaxin binding protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stxbp3 |
| Official Name | syntaxin binding protein 3 [Source:RGD Symbol;Acc:619968] |
| Ensembl ID | ENSRNOG00000020392 |
| Bio databases IDs | |
| Aliases | syntaxin binding protein 3 |
| Synonyms | MUNC18-3, MUNC18C, PSP, Stxbp3a, Sxtbp3, syntaxin binding protein 3, Unc18-3, UNC-18C, UNC-18 homolog 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stxbp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- syntaxin-1 binding
- protein binding
- Sec1 family
- transporter
- syntaxin binding
Pathways
Biological processes and signaling networks where the Stxbp3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- hyperglycemia
- insulin resistance
- dementia
role in cell
- formation
- aggregation
- cell death
- formation in
- docking
- fusion
- exocytosis by
- response by
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- Nucleus
- cytosol
- apical membrane
- basolateral membrane
- basal membrane
- lateral plasma membrane
- alpha granules
- specific granules
- storage granules
- secretory granules
- phagosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stxbp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein to membrane docking
- insulin secretion
- negative regulation of glucose import
- neutrophil degranulation
- brain development
- intracellular protein transport
- negative regulation of calcium ion-dependent exocytosis
- neurotransmitter secretion
- response to insulin stimulus
- vesicle-mediated transport
- cellular glucose homeostasis
- vesicle docking involved in exocytosis
- cellular response to interferon-gamma
- platelet aggregation
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule
- extracellular vesicular exosome
- specific granule
- secretory granule
- phagocytic vesicle
- tertiary granule
- cytosol
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- syntaxin binding
- syntaxin-1 binding