Sf3b4 Gene Summary [Rat]
Predicted to enable RNA binding activity and splicing factor binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of U12-type spliceosomal complex; U2 snRNP; and U2-type precatalytic spliceosome. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Nager acrofacial dysostosis; cervical cancer; and hepatocellular carcinoma. Orthologous to human SF3B4 (splicing factor 3b subunit 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sf3b4 |
| Official Name | splicing factor 3b, subunit 4 [Source:RGD Symbol;Acc:1309667] |
| Ensembl ID | ENSRNOG00000021181 |
| Bio databases IDs | |
| Aliases | splicing factor 3b, subunit 4 |
| Synonyms | AFD1, Hsh49, SAP49, SF3b49, SF3b50, SPLICING FACTOR 3B subunit4, splicing factor 3b, subunit 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sf3b4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- protein binding
Pathways
Biological processes and signaling networks where the Sf3b4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial neoplasia
- epithelial cancer
- lung adenocarcinoma formation
- Nager syndrome
- acute myeloid leukemia
- brain glioma
- brain glioma formation
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
role in cell
- proliferation
- expression in
- differentiation
- migration
- cell proliferation
- dipeptide repeat protein sensitivity
- invasion by
- splicing by
- Clathrin mediated endocytosis by
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Plasma Membrane
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sf3b4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing, via transesterification reactions
- RNA splicing
- positive regulation of nuclear mRNA splicing, via spliceosome
- mRNA processing
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- U12-type spliceosomal complex
- spliceosomal complex
- U2-type spliceosomal complex
- U2-type precatalytic spliceosome
- U2 snRNP
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding