Cldn1 Gene Summary [Rat]
Predicted to enable identical protein binding activity and virus receptor activity. Involved in several processes, including cellular response to butyrate; cellular response to cytokine stimulus; and endothelial cell development. Located in apical plasma membrane; bicellular tight junction; and lateral plasma membrane. Biomarker of diabetic retinopathy; liver disease (multiple); and periodontitis. Human ortholog(s) of this gene implicated in Crohn's disease and atopic dermatitis. Orthologous to human CLDN1 (claudin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cldn1 |
| Official Name | claudin 1 [Source:RGD Symbol;Acc:68422] |
| Ensembl ID | ENSRNOG00000001926 |
| Bio databases IDs | |
| Aliases | claudin 1 |
| Synonyms | Claudin, Claudin-1, CLD1, ILVASC, SEMP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cldn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- viral receptor
- cytoplasmic domain
- ectodomain
- PMP-22/EMP/MP20/Claudin family
- extracellular loop
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Cldn1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- breast cancer
- metastasis
- organismal death
- non-small cell lung cancer
- NISCH syndrome
- colon adenocarcinoma
- colon epithelial cancer
- asthma
role in cell
- proliferation
- apoptosis
- phosphorylation in
- expression in
- migration
- invasion
- activation in
- quantity
- formation
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- soluble fraction
- cell junction
- cell surface
- intracellular space
- cellular membrane
- intercellular junctions
- cell-cell contacts
- tight junctional strands
- lateral cell surfaces
- apical membrane
- basolateral membrane
- basal membrane
- lateral plasma membrane
- paranodal loops
- paranodes
- internodes
- cytoplasmic vesicles
- endolysosomes
- tight junctions
- junctional complexes
- basement membrane
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cldn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- calcium-independent cell-cell adhesion
- positive regulation of wound healing
- cell junction maintenance
- establishment of blood-nerve barrier
- positive regulation of epithelial cell proliferation involved in wound healing
- cell adhesion
- response to toxin
- establishment of skin barrier
- cell-cell junction organization
- cellular response to lead ion
- response to ethanol
- cellular response to transforming growth factor beta stimulus
- response to interleukin-18
- tight junction assembly
- cellular response to tumor necrosis factor
- response to lipopolysaccharide
- cellular response to interferon-gamma
- maintenance of blood-brain barrier
- protein oligomerization
- positive regulation of cell migration
- response to dexamethasone stimulus
Cellular Component
Where in the cell the gene product is active
- tight junction
- occluding junction
- lateral plasma membrane
- membrane
- macromolecular complex
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- structural molecule activity
- viral receptor activity