Habp2 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase activity. Involved in response to bleomycin. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of pulmonary fibrosis. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma and thrombophilia due to thrombin defect. Orthologous to human HABP2 (hyaluronan binding protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Habp2 |
| Official Name | hyaluronan binding protein 2 [Source:RGD Symbol;Acc:1302979] |
| Ensembl ID | ENSRNOG00000016659 |
| Bio databases IDs | |
| Aliases | hyaluronan binding protein 2 |
| Synonyms | AI035669, FSAP, HABP, HGFAL, hyaluronan binding protein 2, hyaluronic acid binding protein 2, NMTC5, PHBP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Habp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- KR
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- peptidase
- serine protease domain
- glycosaminoglycan binding
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- liver cancer
- behavioral deficit
- bleeding
- acute respiratory distress syndrome
- susceptibility to venous thromboembolism
- Staphylococcus aureus pneumonia
- susceptibility to nonmedullary thyroid cancer type 5
- pancreatic neoplasia
role in cell
- expression in
- phosphorylation in
- proliferation
- apoptosis
- migration
- molecular cleavage in
- adhesion
- generation in
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Habp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- glycosaminoglycan binding
- calcium ion binding
- serine-type endopeptidase activity
- peptidase activity