LOC103690054 Gene Summary [Rat]

Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II; transcription initiation at RNA polymerase II promoter; and transcription-coupled nucleotide-excision repair. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II, core complex. Orthologous to human POLR2I (RNA polymerase II subunit I). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
LOC103690054
Official Name
DNA-directed RNA polymerase II subunit RPB9 [Source:RGD Symbol;Acc:9095262]
Ensembl ID
ENSRNOG00000020799
Bio databases IDs NCBI: 103690054 NCBI: 292778 Ensembl: ENSRNOG00000020799
Aliases DNA-directed RNA polymerase II subunit RPB9
Synonyms 2810002B19Rik, hRPB14.5, LOC100911822, LOC103690054, polymerase (RNA) II (DNA directed) polypeptide I, RNA polymerase II subunit I, RPB9
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc103690054 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • transcription regulator
  • zinc ion binding
  • DNA-directed RNA polymerase
  • Zn-ribbon
  • RNA polymerases M/15 Kd subunit
  • protein binding

Pathways

Biological processes and signaling networks where the Loc103690054 gene in rat plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • Huntington disease
  • hypertensive renal disease
  • brain cancer
  • infection by HIV-1
regulated by
regulates
  • DNA promoter
  • DNA endogenous promoter
  • RNA polymerase II

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Loc103690054 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • transcription-coupled nucleotide-excision repair
  • maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter
  • transcription from RNA polymerase II promoter
  • transcription initiation from RNA polymerase II promoter

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • nucleolus
  • DNA-directed RNA polymerase II, core complex
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • nucleic acid binding
  • zinc ion binding
  • protein binding
  • DNA-directed RNA polymerase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.