Polr2i

Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II; transcription initiation at RNA polymerase II promoter; and transcription-coupled nucleotide-excision repair. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II, core complex. Is expressed in several structures, including alimentary system; blastocyst; integumental system; nervous system; and urinary system. Orthologous to human POLR2I (RNA polymerase II subunit I). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polr2i often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Polr2i gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Polr2i gene, providing context for its role in the cell.