POLR2I Gene Summary [Human]
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | POLR2I |
| Official Name | RNA polymerase II subunit I [Source:HGNC Symbol;Acc:HGNC:9196] |
| Ensembl ID | ENSG00000105258 |
| Bio databases IDs | |
| Aliases | RNA polymerase II subunit I |
| Synonyms | 2810002B19Rik, hRPB14.5, LOC100911822, LOC103690054, polymerase (RNA) II (DNA directed) polypeptide I, RNA polymerase II subunit I, RPB9 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR2I often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- zinc ion binding
- DNA-directed RNA polymerase
- Zn-ribbon
- RNA polymerases M/15 Kd subunit
- protein binding
Pathways
Biological processes and signaling networks where the POLR2I gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR2I gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription-coupled nucleotide-excision repair
- maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter
- transcription from RNA polymerase II promoter
- transcription initiation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- DNA-directed RNA polymerase II, core complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- zinc ion binding
- protein binding
- DNA-directed RNA polymerase activity