FGF3 Gene Summary [Human]
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FGF3 |
| Official Name | fibroblast growth factor 3 [Source:HGNC Symbol;Acc:HGNC:3681] |
| Ensembl ID | ENSG00000186895 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 3, INT-2 proto-oncogene protein, oncogene INT2, V-INT2 murine mammary tumor virus integration site oncogene homolog, murine mammary tumor virus integration site 2, mouse |
| Synonyms | Fgf5c, fibroblast growth factor 3, HBGF-3, INT2, Int-P |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FGF3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- nuclear localization sequence
- signal peptide
- protein binding
- nucleolar targeting motif
- growth factor
Pathways
Biological processes and signaling networks where the FGF3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck squamous cell carcinoma
- hyperactive behavior
- cancer
- epithelial neoplasia
- epithelial cancer
- growth failure
- Michel aplasia with microtia and microdontia
- head and neck squamous cell cancer
- breast cancer metastatic to brain
- brain metastasis
role in cell
- phosphorylation in
- expression in
- proliferation
- survival
- differentiation
- transformation
- quantity
- growth
- cellular infiltration by
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- perinuclear region
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- medial face of the Golgi apparatus
- dense fibrillar component
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FGF3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- positive regulation of cell proliferation
- cell-cell signaling
- fibroblast growth factor receptor signaling pathway
- anatomical structure morphogenesis
- positive regulation of MAPK cascade
- organ morphogenesis
- positive regulation of cell division
- positive regulation of gene expression
- positive regulation of protein phosphorylation
- cell differentiation
- negative regulation of cardiac muscle tissue development
- regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- fibroblast growth factor receptor binding