Nucb1 Gene Summary [Rat]
Enables G-protein alpha-subunit binding activity; calcium ion binding activity; and guanyl-nucleotide exchange factor activity. Involved in regulation of protein targeting and small GTPase-mediated signal transduction. Located in Golgi apparatus; cytoplasmic vesicle; and extracellular space. Is extrinsic component of Golgi membrane. Orthologous to human NUCB1 (nucleobindin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nucb1 |
| Official Name | nucleobindin 1 [Source:RGD Symbol;Acc:620030] |
| Ensembl ID | ENSRNOG00000020889 |
| Bio databases IDs | |
| Aliases | nucleobindin 1 |
| Synonyms | B230337F23RIK, CALNUC, MTEST82, NUC, NUCB, nucleobindin 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nucb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand domain pair
- guanyl-nucleotide exchange factor
- calcium ion binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Extracellular Space
- cellular membrane
- Golgi Apparatus
- ER-to-Golgi intermediate compartment
- endoplasmic reticulum lumen
- cis face of the Golgi apparatus
- Golgi membrane
- trans Golgi network
- cis Golgi networks
- early endosomes
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nucb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- membrane
- Golgi apparatus
- endoplasmic reticulum-Golgi intermediate compartment
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- G-protein alpha-subunit binding
- calcium ion binding
- guanyl-nucleotide exchange factor activity