Dcc Gene Summary [Rat]
Enables identical protein binding activity; netrin receptor activity; and transcription coactivator activity. Involved in several processes, including nervous system development; positive regulation of ERK1 and ERK2 cascade; and response to amphetamine. Located in growth cone membrane. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dcc |
| Official Name | DCC netrin 1 receptor [Source:RGD Symbol;Acc:2492] |
| Ensembl ID | ENSRNOG00000033099 |
| Bio databases IDs | |
| Aliases | DCC netrin 1 receptor |
| Synonyms | C030036D22RIK, Colorectal Ca+ supp, CRC18, CRCR1, DCC netrin 1 receptor, HGPPS2, IGDCC1, MRMV1, NTN1R1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dcc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- palmitoylation site
- Neogenin C-terminus
- proapoptotic domain
- transcription co-activator
- immunoglobulin domain
- ectodomain
- Purple acid Phosphatase, N-terminal domain
- Immunoglobulin I-set domain
- protein binding
- Fibronectin type 3 domain
- Interferon-alpha/beta receptor, fibronectin type III
- identical protein binding
- IgG-C2 domain
- FNIII-like repeat
- cytoplasmic domain
- FN3
- Immunoglobulin like
- transmembrane domain
- intracellular domain
- transmembrane receptor
- Immunoglobulin V-set domain
- netrin receptor
Pathways
Biological processes and signaling networks where the Dcc gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- hypertension
- neck pain
- backache
- major depression
- neoplasia
- COVID-19
- schizophrenia
- Parkinson disease
- epithelial cancer
role in cell
- binding
- expression in
- adhesion
- phosphorylation in
- apoptosis
- activation in
- migration
- cell death
- proliferation
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble fractions
- Cytoplasm
- cell surface
- membrane surface
- cellular membrane
- cytosol
- synaptic membrane
- growth cone
- neurites
- synapse
- filopodia
- perikaryon
- axons
- dendrites
- excitatory synapses
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dcc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of dendrite development
- negative regulation of collateral sprouting
- neuron migration
- negative regulation of neuron projection development
- axonogenesis
- apoptotic process
- axon guidance
- anterior/posterior axon guidance
- spinal cord ventral commissure morphogenesis
- dorsal/ventral axon guidance
Cellular Component
Where in the cell the gene product is active
- axonal growth cone
- cytosol
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding