Rtn4rl2 Gene Summary [Rat]
Enables signaling receptor activity. Involved in cell surface receptor signaling pathway and negative regulation of neuron projection development. Located in several cellular components, including external side of plasma membrane; membrane raft; and perikaryon. Orthologous to human RTN4RL2 (reticulon 4 receptor like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rtn4rl2 |
| Official Name | reticulon 4 receptor-like 2 [Source:RGD Symbol;Acc:727797] |
| Ensembl ID | ENSRNOG00000021513 |
| Bio databases IDs | |
| Aliases | reticulon 4 receptor-like 2 |
| Synonyms | NgR2, NGRH1, Ngrl3, reticulon 4 receptor-like 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rtn4rl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leucine-rich repeat
- protein phosphatase 1 regulatory subunit 42
- signaling receptor activity
- ectodomain
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- papillary thyroid carcinoma
- papillary thyroid cancer
- Hodgkin lymphoma
- Hodgkin disease
role in cell
- outgrowth
- growth
- expression in
- function
- motility
- binding
- development
- morphology
- regeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- plasma membrane extracellular face
- neurites
- membrane rafts
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rtn4rl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of neuron projection development
- cell surface receptor signaling pathway
- axon regeneration
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- extracellular region
- perikaryon
- neuron projection
- plasma membrane
- cell surface
- dendrite
- extracellular space
- extracellular vesicular exosome
- membrane raft
- extracellular matrix
- axon
Molecular Function
What the gene product does at the molecular level
- signaling receptor activity