Pygm Gene Summary [Rat]
Enables carbohydrate binding activity; glycogen phosphorylase activity; and heterocyclic compound binding activity. Involved in several processes, including glycogen catabolic process; response to cAMP; and response to hypoxia. Located in sarcoplasmic reticulum. Used to study cholestasis. Human ortholog(s) of this gene implicated in glycogen storage disease V. Orthologous to human PYGM (glycogen phosphorylase, muscle associated). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pygm |
| Official Name | glycogen phosphorylase, muscle associated [Source:RGD Symbol;Acc:3461] |
| Ensembl ID | ENSRNOG00000021090 |
| Bio databases IDs | |
| Aliases | glycogen phosphorylase, muscle associated |
| Synonyms | glycogen phosphorylase, muscle associated, GP, GSD5, M-GP, Muscle glycogen phosphorylase, Muscpho, myophosphorylase, PG, PHOS A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pygm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycosyltransferase family 1 and related proteins with GTB topology
- pyridoxal phosphate binding
- AMP binding
- Carbohydrate phosphorylase
- glycogen/starch/alpha-glucan phosphorylases
- enzyme
- protein binding
- carbohydrate binding
- phosphorylase
- glycogen phosphorylase
Pathways
Biological processes and signaling networks where the Pygm gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- glycogen storage disease V
- androgenic alopecia
- glycogen storage disease
- rhabdomyolysis
regulates
- Ca2+
- MBP
- glycogen
- glycogen synthase
role in cell
- proliferation
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- sarcoplasmic reticulum
- cytosol
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pygm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycogen metabolic process
- glycogen catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- glycogen phosphorylase activity
- pyridoxal phosphate binding
- protein binding