Macrod1 Gene Summary [Rat]
Predicted to enable ADP-ribosylglutamate hydrolase activity and deacetylase activity. Predicted to be involved in DNA damage response; peptidyl-glutamate ADP-deribosylation; and purine nucleoside metabolic process. Predicted to be located in mitochondrion and nucleus. Predicted to be active in nucleoplasm. Orthologous to human MACROD1 (mono-ADP ribosylhydrolase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Macrod1 |
| Official Name | mono-ADP ribosylhydrolase 1 [Source:RGD Symbol;Acc:628701] |
| Ensembl ID | ENSRNOG00000021174 |
| Bio databases IDs | |
| Aliases | mono-ADP ribosylhydrolase 1 |
| Synonyms | AW743046, D930010J01Rik, LRP16, MDO1, mono-ADP ribosylhydrolase 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Macrod1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- macro domain
- N-glycosyl glycosylase
- macrodomain superfamily
- glycosylase
- enzyme
- protein binding
- deacetylase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- lung squamous cell carcinoma
- lung adenocarcinoma
- lung adenocarcinoma formation
- schizophrenia
- organismal death
- hepatitis A
- bipolar disorder
- inflammatory bowel disease
- Sengers syndrome
regulates
- AHR
- ADP ribose 1''-phosphate
- purine nucleoside
role in cell
- tubulation
- fragmentation in
- tubulation in
- fragmentation
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Macrod1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein de-ADP-ribosylation
- purine nucleoside metabolic process
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- deacetylase activity
- hydrolase activity, acting on glycosyl bonds