Wapl Gene Summary [Rat]
Predicted to enable ATP-dependent protein-DNA unloader activity. Predicted to be involved in several processes, including negative regulation of DNA replication; negative regulation of sister chromatid cohesion; and protein localization to chromatin. Predicted to be located in several cellular components, including intercellular bridge; mitotic spindle; and nucleoplasm. Orthologous to human WAPL (WAPL cohesin release factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wapl |
| Official Name | WAPL cohesin release factor [Source:RGD Symbol;Acc:1590924] |
| Ensembl ID | ENSRNOG00000052513 |
| Bio databases IDs | |
| Aliases | WAPL cohesin release factor |
| Synonyms | A530089A20Rik, DIF-2, FOE, HWAPL, KIAA0261, RGD1308960, WAPAL, WAPL cohesin release factor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wapl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wings apart-like protein regulation of heterochromatin
- enzyme
- protein binding
- DNA dependent ATPase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- migraines
- squamous-cell carcinoma
- squamous cell cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- cervical intraepithelial neoplasia
role in cell
- proliferation
- condensation
- expression in
- cell death
- invasion by
- migration
- quantity
- binding
- cell cycle progression
- aneuploidization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- cytoplasmic bridges
- cytosol
- chromosome
- nucleoplasm
- mitotic spindle
- centromeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wapl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- negative regulation of chromatin binding
- protein localization to chromatin
- mitotic sister chromatid segregation
- negative regulation of sister chromatid cohesion
- negative regulation of DNA replication
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- mitotic spindle
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- chromosome
- chromosome, centromeric region
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding