Meis3 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding activity; and sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including angiogenesis; embryonic pattern specification; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of apoptotic signaling pathway and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in nucleus. Orthologous to several human genes including MEIS3 (Meis homeobox 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Meis3 |
| Official Name | Meis homeobox 3 [Source:RGD Symbol;Acc:1308532] |
| Ensembl ID | ENSRNOG00000021390 |
| Bio databases IDs | |
| Aliases | Meis homeobox 3 |
| Synonyms | Meis homeobox 3, MRG2, Myeloid ecotropic viral integration site-related gene 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Meis3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- N-terminal of Homeobox Meis and PKNOX1
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Meis3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- eye development
- embryonic pattern specification
- positive regulation of cell proliferation
- brain development
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of protein kinase B signaling cascade
- negative regulation of apoptotic signaling pathway
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity