Meis2 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in pancreas development; response to growth factor; and response to mechanical stimulus. Predicted to be located in nucleus. Biomarker of brain infarction. Human ortholog(s) of this gene implicated in cleft palate; cleft palate, cardiac defects, and intellectual disability; learning disability; open-angle glaucoma; and orofacial cleft. Orthologous to human MEIS2 (Meis homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Meis2 |
| Official Name | Meis homeobox 2 [Source:RGD Symbol;Acc:1305198] |
| Ensembl ID | ENSRNOG00000004730 |
| Bio databases IDs | |
| Aliases | Meis homeobox 2 |
| Synonyms | A430109D20Rik, CPCMR, HsT18361, LOC100909762, Meis homeobox 2, MRG1, Stra10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Meis2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- transcription activation domain
- transcription factor binding
- protein binding
- N-terminal of Homeobox Meis and PKNOX1
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- MEIS domain
- homeodomain
Pathways
Biological processes and signaling networks where the Meis2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- anemia
- diabetes mellitus
- bleeding
- Huntington disease
- idiopathic scoliosis
- cleft palate
- preeclampsia
- hereditary disorder
- cleft palate, cardiac defects and mental retardation
role in cell
- apoptosis
- expression in
- activation in
- differentiation
- S phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Meis2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of myeloid cell differentiation
- response to growth factor stimulus
- embryonic pattern specification
- positive regulation of cell proliferation
- visual learning
- brain development
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of mitotic cell cycle
- organ morphogenesis
- response to mechanical stimulus
- negative regulation of transcription from RNA polymerase II promoter
- eye development
- pancreas development
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- transcription factor binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity