MEIS3 Gene Summary [Human]
This gene encodes a homeobox protein and probable transcriptional regulator. The orthologous protein in mouse controls expression of 3-phosphoinositide dependent protein kinase 1, which promotes survival of pancreatic beta-cells. [provided by RefSeq, Sep 2016]
Details
| Type | Retained Intron |
| Official Symbol | MEIS3 |
| Official Name | Meis homeobox 3 [Source:HGNC Symbol;Acc:HGNC:29537] |
| Ensembl ID | ENSG00000105419 |
| Bio databases IDs | |
| Aliases | Meis homeobox 3 |
| Synonyms | Meis homeobox 3, MRG2, Myeloid ecotropic viral integration site-related gene 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MEIS3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- N-terminal of Homeobox Meis and PKNOX1
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MEIS3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- eye development
- embryonic pattern specification
- positive regulation of cell proliferation
- brain development
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of protein kinase B signaling cascade
- negative regulation of apoptotic signaling pathway
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity