Timp1 Gene Summary [Rat]
Enables protease binding activity. Involved in several processes, including cartilage development; cellular response to peptide; and response to peptide hormone. Located in basement membrane. Used to study degenerative disc disease. Biomarker of several diseases, including gastric ulcer; heart disease (multiple); lung disease (multiple); metabolic dysfunction-associated steatohepatitis; and vascular disease (multiple). Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Timp1 |
| Official Name | TIMP metallopeptidase inhibitor 1 [Source:RGD Symbol;Acc:621675] |
| Ensembl ID | ENSRNOG00000010208 |
| Bio databases IDs | |
| Aliases | TIMP metallopeptidase inhibitor 1 |
| Synonyms | CLGI, EPA, EPO, HCI, Metalloproteinase inhibitor, TIMP, TIMP metallopeptidase inhibitor 1, Tissue Inhibitor of Metalloproteinase 1, TPA-S1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Timp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NTR_like
- MMP binding ridge
- protease binding
- zinc ion binding
- protease inhibitor
- N-linked glycosylation site
- EF loop
- protein binding
- cytokine
- loop domain
- metalloendopeptidase inhibitor
- Tissue inhibitor of metalloproteinase
Pathways
Biological processes and signaling networks where the Timp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- coronary disease
- atherosclerosis
- epithelial cancer
- cancer
- metastasis
- neoplasia
- plasma cell myeloma
- COVID-19
- papillary thyroid carcinoma
role in cell
- number
- proliferation
- G1 phase
- differentiation
- expression in
- activation
- growth
- cell death
- activation in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular vesicles
- Cytoplasm
- cell surface
- basal compartment
- Nucleus
- cytoplasmic particles
- endoplasmic reticulum lumen
- alpha granules
- extracellular matrix
- perikaryon
- dendrites
- exosomes
- plasma
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Timp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- regulation of integrin-mediated signaling pathway
- signal transduction
- positive regulation of cell proliferation
- response to hormone stimulus
- response to peptide hormone stimulus
- connective tissue replacement involved in inflammatory response wound healing
- cellular response to UV-A
- negative regulation of catalytic activity
- negative regulation of membrane protein ectodomain proteolysis
- negative regulation of apoptotic process
- negative regulation of endopeptidase activity
- cartilage development
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- endoplasmic reticulum lumen
- basement membrane
- extracellular space
- extracellular vesicular exosome
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- peptidase inhibitor activity
- zinc ion binding
- growth factor activity
- protein binding
- protease binding
- metalloendopeptidase inhibitor activity
- cytokine activity