Cspp1 Gene Summary [Rat]
Predicted to be involved in positive regulation of cytokinesis. Predicted to be located in microtubule cytoskeleton and nucleoplasm. Predicted to be active in centrosome and spindle pole. Human ortholog(s) of this gene implicated in Joubert syndrome 21. Orthologous to human CSPP1 (centrosome and spindle pole associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cspp1 |
| Official Name | centrosome and spindle pole associated protein 1 [Source:RGD Symbol;Acc:1307055] |
| Ensembl ID | ENSRNOG00000021718 |
| Bio databases IDs | |
| Aliases | centrosome and spindle pole associated protein 1 |
| Synonyms | 2310020J12RIK, 4930413O22Rik, centrosome and spindle pole associated protein 1, CSPP, Cspp2, Cspp3, JBTS21, RGD1307055 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cspp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- Joubert syndrome type 21
- ductal breast carcinoma
- ductal breast cancer
- liver cancer
- Meckel syndrome
- infection by HIV-1
role in cell
- formation in
- cytokinesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- spindle apparatus
- cilia
- basal bodies
- centrosome
- desmosomes
- nucleoplasm
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cspp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell division
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- centriolar satellite
- spindle pole
- spindle
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding