Dok7 Gene Summary [Rat]
Predicted to enable phosphatidylinositol binding activity; protein kinase binding activity; and signaling adaptor activity. Predicted to be involved in several processes, including positive regulation of Rac protein signal transduction; positive regulation of protein tyrosine kinase activity; and positive regulation of skeletal muscle acetylcholine-gated channel clustering. Predicted to act upstream of or within positive regulation of protein phosphorylation and receptor clustering. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in neuromuscular junction and postsynaptic membrane. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 10 and fetal akinesia deformation sequence syndrome 3. Orthologous to human DOK7 (docking protein 7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dok7 |
| Official Name | docking protein 7 [Source:RGD Symbol;Acc:1566416] |
| Ensembl ID | ENSRNOG00000022419 |
| Bio databases IDs | |
| Aliases | docking protein 7 |
| Synonyms | A930013K19Rik, AW049091, C4orf25, CMS10, CMS1B, docking protein 7, EF-12, FADS3, LOC102724043, MDCMP, Oit5, RGD1566416 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dok7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- PTB domain (IRS-1 type)
- protein binding activity, bridging
- protein binding
- Pleckstrin homology-like domain
- Src-homology 2 binding domain
- phosphatidylinositol binding
Pathways
Biological processes and signaling networks where the Dok7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- neoplasia
- familial limb-girdle myasthenia
- fetal akinesia deformation sequence 3
- congenital myasthenic syndrome
- insomnia
- hereditary disorder
- coronary artery disease
- akinesia
- bladder cancer
role in cell
- migration
- invasion by
- formation
- proliferation
- formation in
- activation in
- phosphorylation in
- G1/S phase transition
- area
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Mitochondria
- postsynaptic membrane
- nucleoplasm
- neuromuscular junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dok7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuromuscular junction development
- positive regulation of protein tyrosine kinase activity
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- synapse
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- lipid binding