Tmem201 Gene Summary [Rat]
Predicted to enable actin filament binding activity and lamin binding activity. Predicted to be involved in several processes, including nuclear migration along microtubule; positive regulation of endothelial cell migration; and protein localization to nuclear envelope. Predicted to act upstream of or within fibroblast migration and nuclear migration. Predicted to be located in cortical endoplasmic reticulum; nuclear inner membrane; and spindle pole centrosome. Predicted to be active in nuclear membrane. Orthologous to human TMEM201 (transmembrane protein 201). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem201 |
| Official Name | transmembrane protein 201 [Source:RGD Symbol;Acc:1583947] |
| Ensembl ID | ENSRNOG00000023152 |
| Bio databases IDs | |
| Aliases | transmembrane protein 201 |
| Synonyms | D4Ertd429e, Ima1, NET5, RGD1306651, RP13-15M17.2, SAMP1, transmembrane protein 201 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tmem201 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Protein of unknown function C-terminus (DUF2448)
- lamin binding
- protein binding
- Ima1 N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- organismal death
- metastasis
- rotator cuff injury
- major depression
- Alzheimer disease
regulated by
- metformin
role in cell
- phosphorylation in
- migration
- invasion by
- signaling in
- localization
- organization
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cortical endoplasmic reticulum
- centrosome
- inner nuclear membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tmem201 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear migration along microtubule
- fibroblast migration
Cellular Component
Where in the cell the gene product is active
- nuclear inner membrane
- nuclear membrane
- cytoplasm
- spindle pole
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- lamin binding