Fancf Gene Summary [Rat]
Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in DNA damage response. Predicted to act upstream of or within ovarian follicle development; protein ubiquitination; and spermatogenesis. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of Fanconi anaemia nuclear complex. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group F; adenocarcinoma in situ; and granulosa cell tumor. Orthologous to human FANCF (FA complementation group F). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fancf |
| Official Name | FA complementation group F [Source:RGD Symbol;Acc:1561456] |
| Ensembl ID | ENSRNOG00000023968 |
| Bio databases IDs | |
| Aliases | FA complementation group F |
| Synonyms | A730016A17, FA complementation group F, FAF, Fanconi anaemia, complementation group F, Fanconi anemia, complementation group F, RGD1561456 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fancf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- enzyme
- protein binding
- Fanconi anemia group F protein (FANCF)
Pathways
Biological processes and signaling networks where the Fancf gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- breast cancer
- Fanconi anemia, group F
- Fanconi anemia
- adenoma formation
- benign neoplasia
- azoospermia
role in cell
- apoptosis
- survival
- repair in
- binding in
- DNA damage response
- transcription in
- repression in
- cisplatin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- cytosol
- nucleoplasm
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fancf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- Fanconi anaemia nuclear complex
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding