Fancl Gene Summary [Rat]
Predicted to enable ubiquitin protein ligase activity and ubiquitin protein ligase binding activity. Predicted to be involved in DNA repair and protein monoubiquitination. Predicted to act upstream of or within gamete generation and regulation of cell population proliferation. Predicted to be located in chromatin; nuclear body; and nuclear envelope. Predicted to be part of Fanconi anaemia nuclear complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group L. Orthologous to human FANCL (FA complementation group L). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fancl |
| Official Name | FA complementation group L [Source:RGD Symbol;Acc:1311427] |
| Ensembl ID | ENSRNOG00000027249 |
| Bio databases IDs | |
| Aliases | FA complementation group L |
| Synonyms | 2010322C19Rik, B230118H11Rik, FAAP43, FA complementation group L, Fanconi anaemia, complementation group L, Fanconi anemia, complementation group L, FLJ10335, gcd, PHF9, POG |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fancl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- RWD, DRWD, and ELF domain family
- FANCL UBC-like domain 2
- FANCL UBC-like domain 1
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin protein ligase activity
- FANCL UBC-like domain 3
- ubiquitin-protein transferase activity
- central domain
- enzyme
- protein binding
- FANCL C-terminal domain
Pathways
Biological processes and signaling networks where the Fancl gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- VACTERL
- Fanconi anemia, group L
- Fanconi anemia
- juvenile rheumatoid arthritis
- hereditary disorder
- Fanconi anemia, group A
- nonsyndromic cleft lip and palate
- prostate cancer
- epithelial cancer
role in cell
- proliferation
- cisplatin sensitivity
- number
- DNA damage response
- meiosis
- methyl methanesulfonate sensitivity
- binding in
- transcription in
- cell death
- nicotinamide sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear bodies
- nuclear envelope
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fancl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- gamete generation
- response to DNA damage stimulus
- protein monoubiquitination
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- nuclear body
- Fanconi anaemia nuclear complex
- intracellular membrane-bounded organelle
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- ubiquitin protein ligase binding
- metal ion binding