Sprr3 Gene Summary [Rat]
Predicted to be located in Golgi apparatus and perinuclear region of cytoplasm. Orthologous to human SPRR3 (small proline rich protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sprr3 |
| Official Name | small proline-rich protein 3 [Source:RGD Symbol;Acc:1309589] |
| Ensembl ID | ENSRNOG00000024046 |
| Bio databases IDs | |
| Aliases | small proline-rich protein 3 |
| Synonyms | Cornifin beta, Cornifin β, Esophagin, oesophagin, small proline-rich protein 3, SPRC |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sprr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cornifin (SPRR) family
- protein binding
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- organismal death
- chronic periodontal disease
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
regulates
- AKT
- TP53
role in cell
- activation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cornified envelope
- perinuclear region
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sprr3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- keratinocyte differentiation
- wound healing
- epidermis development
- keratinization
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytosol
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity