Dsg3 Gene Summary [Rat]
Predicted to enable calcium ion binding activity and protein dimerization activity. Predicted to be involved in several processes, including cell-cell junction assembly; negative regulation of p38MAPK cascade; and positive regulation of protein localization. Predicted to be located in cytoplasm; plasma membrane; and tight junction. Predicted to be active in desmosome. Orthologous to human DSG3 (desmoglein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dsg3 |
| Official Name | desmoglein 3 [Source:RGD Symbol;Acc:1592103] |
| Ensembl ID | ENSRNOG00000016632 |
| Bio databases IDs | |
| Aliases | desmoglein 3 |
| Synonyms | ABOLM, bal, CDHF6, desmoglein 3, LOC100505217, pemphigus vulgaris antigen, PVA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dsg3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- extracellular domain
- Cadherin, Y-type LIR-motif
- cytoplasmic domain
- intracellular domain
- Cadherin repeat-like domain
- protein binding
- cytosolic tail domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung squamous cell carcinoma
- conjunctivitis
- epithelial cancer
- parakeratosis
- acantholytic blistering of oral and laryngeal mucosa
- Parkinson disease
- overall survival
- spongiosis
- pemphigus vulgaris
role in cell
- expression in
- cell death
- growth
- migration
- proliferation
- upregulation in
- apoptosis
- activation in
- colony formation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cornified envelope
- cell junction
- Cytoplasm
- cell surface
- cell periphery
- cellular membrane
- intercellular junctions
- desmosomes
- cell-cell contacts
- cytosol
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dsg3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- extracellular vesicular exosome
- cytosol
- desmosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding