Senp6 Gene Summary [Rat]
Predicted to enable SUMO-specific endopeptidase activity. Predicted to be involved in protein desumoylation; regulation of kinetochore assembly; and regulation of spindle assembly. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus; postsynaptic cytosol; and presynaptic cytosol. Orthologous to human SENP6 (SUMO specific peptidase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Senp6 |
| Official Name | SUMO specific peptidase 6 [Source:RGD Symbol;Acc:1304565] |
| Ensembl ID | ENSRNOG00000024336 |
| Bio databases IDs | |
| Aliases | SUMO specific peptidase 6 |
| Synonyms | 2810017C20Rik, E130319N12Rik, FKSG6, mKIAA0797, SSP1, SUMO/sentrin specific peptidase 6, SUMO specific peptidase 6, SUSP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Senp6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine endopeptidase
- catalytic domain
- peptidase
- protein binding
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Senp6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- migraines
- epithelial cancer
- liver cancer
- osteoarthritis
- hepatocellular carcinoma
- cutaneous lupus erythematosus
role in cell
- expression in
- activation in
- quantity
- accumulation in
- size
- assembly
- sumoylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Senp6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of kinetochore assembly
- regulation of spindle assembly
- protein sumoylation
- protein desumoylation
- proteolysis
- protein modification by small protein removal
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- SUMO-specific endopeptidase activity