Senp6 Gene Summary [Mouse]
Predicted to enable SUMO-specific endopeptidase activity. Predicted to be involved in protein desumoylation; regulation of kinetochore assembly; and regulation of spindle assembly. Is active in postsynaptic cytosol and presynaptic cytosol. Is expressed in embryo. Orthologous to human SENP6 (SUMO specific peptidase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Senp6 |
| Official Name | SUMO/sentrin specific peptidase 6 [Source:MGI Symbol;Acc:MGI:1922075] |
| Ensembl ID | ENSMUSG00000034252 |
| Bio databases IDs | |
| Aliases | SUMO/sentrin specific peptidase 6 |
| Synonyms | 2810017C20Rik, E130319N12Rik, FKSG6, mKIAA0797, SSP1, SUMO/sentrin specific peptidase 6, SUMO specific peptidase 6, SUSP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Senp6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine endopeptidase
- catalytic domain
- peptidase
- protein binding
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Senp6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- migraines
- epithelial cancer
- liver cancer
- osteoarthritis
- hepatocellular carcinoma
- cutaneous lupus erythematosus
role in cell
- expression in
- activation in
- quantity
- accumulation in
- size
- assembly
- sumoylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Senp6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of kinetochore assembly
- regulation of spindle assembly
- protein sumoylation
- protein desumoylation
- proteolysis
- protein modification by small protein removal
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- SUMO-specific endopeptidase activity