Lman1 Gene Summary [Rat]
Enables identical protein binding activity. Predicted to be involved in several processes, including Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and negative regulation of protein targeting to mitochondrion. Predicted to act upstream of or within endoplasmic reticulum organization. Located in endoplasmic reticulum-Golgi intermediate compartment. Is active in glutamatergic synapse and postsynaptic Golgi apparatus. Human ortholog(s) of this gene implicated in factor V deficiency and factor XIII deficiency. Orthologous to human LMAN1 (lectin, mannose binding 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lman1 |
| Official Name | lectin, mannose-binding, 1 [Source:RGD Symbol;Acc:71020] |
| Ensembl ID | ENSRNOG00000024470 |
| Bio databases IDs | |
| Aliases | lectin, mannose-binding, 1 |
| Synonyms | 2610020P13Rik, C730041J05, ERGIC-53, F5F8D, FMFD1, Golgi 58k, gp58, lectin, mannose binding 1, lectin, mannose-binding, 1, MCFD1, MR60, P58 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lman1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bacterial lectin
- carbohydrate recognition domain
- legume lectins
- calcium ion binding
- metal ion binding
- protein binding
- identical protein binding
- mannose binding
- sorting signal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- combined deficiency of factor V and factor VIII type 1
- combined factor V-factor VIII deficiency
- Hutchinson-Gilford progeria syndrome
role in cell
- polymerization in
- accumulation in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum fraction
- Golgi-enriched fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- Golgi region
- perinuclear region
- microvesicles
- cellular membrane
- Nucleus
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- sarcomere
- ER-to-Golgi intermediate compartment
- endoplasmic reticulum-Golgi membrane contact site
- endoplasmic reticulum membrane
- medial face of the Golgi apparatus
- Golgi membrane
- trans face of the Golgi apparatus
- cis Golgi networks
- spine apparatus
- transport vesicles
- microsomal membrane
- axons
- pre-Golgi intermediate vesicles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lman1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- protein exit from endoplasmic reticulum
- Golgi organization
- positive regulation of organelle organization
- early endosome to Golgi transport
- blood coagulation
- protein folding
- endoplasmic reticulum organization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- membrane
- ER to Golgi transport vesicle membrane
- Golgi membrane
- ER to Golgi transport vesicle
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment
- sarcomere
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- mannose binding
- metal ion binding
- unfolded protein binding