Mdc1 Gene Summary [Rat]
Predicted to enable histone reader activity. Predicted to be involved in DNA damage response; DNA replication checkpoint signaling; and protein localization to site of double-strand break. Predicted to be located in chromosome; focal adhesion; and nuclear body. Predicted to be active in site of double-strand break. Orthologous to human MDC1 (mediator of DNA damage checkpoint 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Mdc1 |
| Official Name | mediator of DNA damage checkpoint 1 [Source:RGD Symbol;Acc:1559468] |
| Ensembl ID | ENSRNOG00000032813 |
| Bio databases IDs | |
| Aliases | mediator of DNA damage checkpoint 1 |
| Synonyms | 6820401C03, mediator of DNA damage checkpoint 1, mKIAA0170, NFBD1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mdc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Family of unknown function (DUF5585)
- BRCT
- Inner membrane component of T3SS, cytoplasmic domain
- Regulator of Ty1 transposition protein 107 BRCT domain
- FHA domain
- BRCA1 C Terminus (BRCT) domain
- protein binding activity, bridging
- Forkhead associated domain
- Domain of unknown function (DUF4775)
- protein binding
- breast cancer carboxy-terminal domain
- forkhead associated (FHA) domain superfamily
Pathways
Biological processes and signaling networks where the Mdc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- medullary thyroid carcinoma
- gastrointestinal neoplasia
- medullary thyroid cancer
role in cell
- quantity
- phosphorylation in
- formation
- formation in
- survival
- cell death
- G2/M phase
- induction in
- apoptosis
- S phase checkpoint control
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- focal adhesions
- nuclear foci
- chromosome
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mdc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA replication checkpoint
- positive regulation of transcription initiation from RNA polymerase II promoter
- intra-S DNA damage checkpoint
- response to DNA damage stimulus
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- nuclear body
- focal adhesion
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding