Dclre1a Gene Summary [Rat]
Predicted to enable 5'-3' DNA exonuclease activity; beta-lactamase activity; and damaged DNA binding activity. Predicted to be involved in double-strand break repair via nonhomologous end joining and interstrand cross-link repair. Predicted to act upstream of or within nucleotide-excision repair. Predicted to be located in fibrillar center and nucleoplasm. Orthologous to human DCLRE1A (DNA cross-link repair 1A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dclre1a |
| Official Name | DNA cross-link repair 1A [Source:RGD Symbol;Acc:1306156] |
| Ensembl ID | ENSRNOG00000026204 |
| Bio databases IDs | |
| Aliases | DNA cross-link repair 1A |
| Synonyms | 2810043H12Rik, DNA cross-link repair 1A, mKIAA0086, PSO2, Smn1a, SNM1, SNM1A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dclre1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Beta-lactamase superfamily domain
- 5' phosphomonoester producing exodeoxyribonuclease
- 5'-3' exonuclease
- beta-lactamase
- DNA repair metallo-beta-lactamase
- enzyme
- metallo-hydrolase-like_MBL-fold
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- cancer
- adenoma formation
- benign neoplasia
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
regulates
- double-stranded DNA
role in cell
- function
- proliferation
- abnormal morphology
- breakage in
- colony survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- nuclear foci
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dclre1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- double-strand break repair via nonhomologous end joining
Cellular Component
Where in the cell the gene product is active
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- 5'-3' exodeoxyribonuclease activity
- beta-lactamase activity
- damaged DNA binding