Alox12 Gene Summary [Rat]
Predicted to enable arachidonate 12(S)-lipoxygenase activity; arachidonate 15-lipoxygenase activity; and linoleate 13S-lipoxygenase activity. Involved in several processes, including fatty acid metabolic process; positive regulation of endothelial tube morphogenesis; and regulation of apoptotic process. Located in sarcolemma. Biomarker of congestive heart failure; hypertension; and obesity. Orthologous to human ALOX12 (arachidonate 12-lipoxygenase, 12S type). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alox12 |
| Official Name | arachidonate 12-lipoxygenase, 12S type [Source:RGD Symbol;Acc:1311159] |
| Ensembl ID | ENSRNOG00000027037 |
| Bio databases IDs | |
| Aliases | arachidonate 12-lipoxygenase, 12S type |
| Synonyms | 12/15-Lox, 12-lipoxygenase, 12-LO, 12-LOX, 12S LIPOXYGENASE, 12S-LOX, 9930022G08Rik, Alox12p, arachidonate 12-lipoxygenase, arachidonate 12-lipoxygenase, 12S type, LOG12, P-12LO, P(12s)-lox, PLATELET type 12-LO, Platelet Type 12-LOX (ALOX12) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Alox12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipoxygenase
- arachidonate 12-lipoxygenase
- catalytic domain
- PLAT
- arachidonate 15-lipoxygenase
- hepoxilin-epoxide hydrolase
- enzyme
- protein binding
- Lipoxygenase homology 2 (beta barrel) domain
Pathways
Biological processes and signaling networks where the Alox12 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- reperfusion injury
- hypertension
- diarrhea
- proctosigmoiditis
- ulcerative colitis
- psoriatic arthritis
- irritable bowel syndrome
- actinic keratosis
- immunological disorder
- Crohn disease
role in cell
- cell death
- activation in
- apoptosis
- adhesion
- proliferation
- migration
- survival
- tubulation
- aggregation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- cellular membrane
- Plasma Membrane
- Mitochondria
- cytosol
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Alox12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of platelet aggregation
- lipid oxidation
- linoleic acid metabolic process
- superoxide anion generation
- establishment of skin barrier
- lipoxin B4 biosynthetic process
- fatty acid oxidation
- lipoxygenase pathway
- hepoxilin biosynthetic process
- lipid metabolic process
- lipoxin A4 biosynthetic process
- negative regulation of muscle cell apoptotic process
- unsaturated fatty acid metabolic process
- arachidonic acid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- sarcolemma
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- iron ion binding
- arachidonate 12-lipoxygenase activity
- arachidonate 15-lipoxygenase activity
- lipoxygenase activity
- hepoxilin-epoxide hydrolase activity