Tapbpl Gene Summary [Rat]
Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | Tapbpl |
| Official Name | TAP binding protein-like [Source:RGD Symbol;Acc:1307893] |
| Ensembl ID | ENSRNOG00000027552 |
| Bio databases IDs | |
| Aliases | TAP binding protein-like |
| Synonyms | TAP binding protein-like, Tapblp, TAPBPL-R, TAPBP-R |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tapbpl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- binding protein
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tapbpl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptide antigen assembly with MHC class I protein complex
- negative regulation of antigen processing and presentation of peptide antigen via MHC class I
Cellular Component
Where in the cell the gene product is active
- MHC class I peptide loading complex
- Golgi membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- MHC class I protein complex binding
- protein binding