Tek Gene Summary [Rat]
Enables growth factor binding activity. Involved in several processes, including endochondral ossification; positive regulation of angiogenesis; and response to estrogen. Predicted to be located in several cellular components, including basolateral plasma membrane; cytoskeleton; and microvillus. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Biomarker of several diseases, including acute kidney tubular necrosis; brain ischemia; gastric ulcer; goiter; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in arteriovenous malformation; multiple cutaneous and mucosal venous malformations; and renal Wilms' tumor. Orthologous to human TEK (TEK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tek |
| Official Name | TEK receptor tyrosine kinase [Source:RGD Symbol;Acc:620980] |
| Ensembl ID | ENSRNOG00000008587 |
| Bio databases IDs | |
| Aliases | TEK receptor tyrosine kinase |
| Synonyms | AA517024, CD202B, GLC3E, Hyk, STK1, TEK receptor tyrosine kinase, TIE-2, VMCM, VMCM1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tek often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- identical protein binding
- EGF_CA
- Laminin-type epidermal growth factor-like domai
- cytoplasmic domain
- Tie-2 Ig-like domain 1
- Immunoglobulin like
- intracellular domain
- immunoglobulin-like protein domain
- Tyrosine kinase, catalytic domain
- growth factor binding
- transmembrane receptor
- extracellular domain
- Protein kinase (unclassified specificity)
- signaling receptor activity
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- immunoglobulin domain
- ectodomain
- Human growth factor-like EGF
- Purple acid Phosphatase, N-terminal domain
- protein binding
- EGF-like domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- signal sequence domain
- transmembrane receptor protein tyrosine kinase
- FN3
- transmembrane domain
- cytosolic tail domain
- substrate binding domain
Pathways
Biological processes and signaling networks where the Tek gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- cutaneous melanoma
- epithelial cancer
- cancer
- pancreatic endocrine tumor
- well-differentiated neuroendocrine tumor
- hepatocellular carcinoma
- colorectal cancer
- metastatic colorectal cancer
role in cell
- phosphorylation in
- cell death
- activation in
- apoptosis
- expression in
- recruitment
- osteoclastogenesis
- proliferation
- growth
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- extracellular matrix fraction
- Cytoplasm
- cell surface
- cell periphery
- apical compartment
- perinuclear region
- cellular membrane
- basal bodies
- centrosome
- actin filaments
- intercellular junctions
- apical membrane
- basolateral membrane
- basal membrane
- actin stress fibers
- membrane rafts
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tek gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rac protein signal transduction
- negative regulation of angiogenesis
- positive regulation of Rho protein signal transduction
- response to estrogen stimulus
- multicellular organismal development
- sprouting angiogenesis
- response to cAMP
- heart trabecula formation
- positive regulation of angiogenesis
- heart development
- response to hypoxia
- angiogenesis
- substrate adhesion-dependent cell spreading
- positive regulation of kinase activity
- negative regulation of endothelial cell apoptotic process
- positive regulation of endothelial cell migration
- regulation of endothelial cell apoptotic process
- negative regulation of inflammatory response
- cell-cell signaling
- transmembrane receptor protein tyrosine kinase signaling pathway
- regulation of vascular permeability
- positive regulation of MAPK cascade
- response to peptide hormone stimulus
- definitive hemopoiesis
- regulation of establishment or maintenance of cell polarity
- positive regulation of focal adhesion assembly
- Tie receptor signaling pathway
- negative regulation of apoptotic process
- glomerulus vasculature development
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- endothelial cell proliferation
- endochondral ossification
- positive regulation of endothelial cell proliferation
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- centriolar satellite
- receptor complex
- extracellular region
- actin filament
- plasma membrane
- cell surface
- basal plasma membrane
- cell-cell junction
- focal adhesion
- cytoplasm
- microvillus
- stress fiber
- membrane raft
- basolateral plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- growth factor binding
- identical protein binding
- protein binding
- transmembrane receptor protein tyrosine kinase activity
- signaling receptor activity
- protein kinase activity