Cnn1 Gene Summary [Rat]
Enables actin binding activity. Predicted to be involved in actin filament organization and negative regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in cytoskeleton. Predicted to be active in actin cytoskeleton. Orthologous to human CNN1 (calponin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cnn1 |
| Official Name | calponin 1 [Source:RGD Symbol;Acc:621883] |
| Ensembl ID | ENSRNOG00000027736 |
| Bio databases IDs | |
| Aliases | calponin 1 |
| Synonyms | Calponin 1, CALPONIN H1, Calporin, CN, Cnnh1, CnnI, HEL-S-14, Sm-Calp, SMCC |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cnn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calponin homology domain
- actin binding
- Calponin family repeat
- calponin homology (CH) domain superfamily
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- endometrial cancer
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- breast carcinoma
- osteosarcoma
- osteosarcomagenesis
- Marfan syndrome
- bleeding
- Alzheimer disease
role in cell
- proliferation
- quantity
- retraction
- dissemination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- microfilaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cnn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actomyosin structure organization
- actin filament organization
- regulation of smooth muscle contraction
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- focal adhesion
- actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- calmodulin binding
- protein binding