Fcar Gene Summary [Rat]
Predicted to be involved in immune response-regulating signaling pathway. Predicted to act upstream of or within defense response to virus and detection of virus. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human NCR1 (natural cytotoxicity triggering receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fcar |
| Official Name | Fc fragment of IgA receptor [Source:RGD Symbol;Acc:1303082] |
| Ensembl ID | ENSRNOG00000027855 |
| Bio databases IDs | |
| Aliases | Fc fragment of IgA receptor |
| Synonyms | CD89, CTB-61M7.2, FcalphaR, Fc alpha receptor, FC alpha receptor 1, Fc alpha RI, Fc α receptor, FC α receptor 1, Fc α RI |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fcar often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytoplasmic domain
- immunoglobulin domain
- ectodomain
- transmembrane domain
- intracellular domain
- IgA binding
- transmembrane receptor
- IgA receptor
Pathways
Biological processes and signaling networks where the Fcar gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- proteinuria
- renal cell carcinoma
- renal cell cancer
- hematuria
- sepsis
- IgA nephropathy
- systemic lupus erythematosus
- experimental crescentic glomerulonephritis
- septic shock
role in cell
- production in
- binding
- growth
- phosphorylation in
- cell death
- apoptosis
- cellular infiltration by
- activation
- phagocytosis
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- secretory granule membrane
- tertiary granule membrane
- specific granule membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fcar gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response-regulating signaling pathway
- immune response
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
- tertiary granule membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- IgA binding