Arhgef18

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of stress fiber assembly and protein localization to cell-cell junction. Predicted to act upstream of or within actin cytoskeleton organization; regulation of cell shape; and small GTPase-mediated signal transduction. Predicted to be located in apical part of cell; cytosol; and plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arhgef18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Arhgef18 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Arhgef18 gene, providing context for its role in the cell.