Nup160 Gene Summary [Rat]
Predicted to be a structural constituent of nuclear pore. Predicted to be involved in mRNA export from nucleus and nephron development. Predicted to be located in kinetochore and nuclear envelope. Predicted to be part of nuclear pore outer ring. Human ortholog(s) of this gene implicated in nephrotic syndrome type 19. Orthologous to human NUP160 (nucleoporin 160). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nup160 |
| Official Name | nucleoporin 160 [Source:RGD Symbol;Acc:1311052] |
| Ensembl ID | ENSRNOG00000028215 |
| Bio databases IDs | |
| Aliases | nucleoporin 160 |
| Synonyms | 2810011M03Rik, AA414952, AU020188, Gtl1-13, Gtl-13, KIAA0197, mKIAA0197, NPHS19, nucleoporin 160, NUP120 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nup160 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nucleoporin Nup120/160
- structural constituent of nuclear pore
- protein binding
Pathways
Biological processes and signaling networks where the Nup160 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- neuroticism
- obesity
- non-insulin-dependent diabetes mellitus
- nephrotic syndrome type 19
- overnutrition
- Alzheimer disease
- depressive disorder
- nonlobar intracerebral hemorrhage
- infection by HIV-1
regulates
role in cell
- cell death
- recruitment in
- nucleation in
- nucleation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- metaphase plate
- cytosol
- nuclear pores
- inner nuclear membrane
- spindle pole
- nuclear envelope
- kinetochores
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nup160 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- nucleocytoplasmic transport
- protein transport
- nephron development
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- Nup107-160 complex
- cytosol
- kinetochore
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of nuclear pore