Fat4 Gene Summary [Rat]
Predicted to enable calcium ion binding activity. Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; hippo signaling; and nervous system development. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; condensed mesenchymal cell proliferation; and ossification involved in bone maturation. Predicted to be located in apical part of cell. Human ortholog(s) of this gene implicated in Hennekam syndrome and Van Maldergem syndrome 2. Orthologous to human FAT4 (FAT atypical cadherin 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fat4 |
| Official Name | FAT atypical cadherin 4 [Source:RGD Symbol;Acc:1564291] |
| Ensembl ID | ENSRNOG00000028335 |
| Bio databases IDs | |
| Aliases | FAT atypical cadherin 4 |
| Synonyms | 6030410K14Rik, 9430004M15, CDHF14, CDHR11, FAT atypical cadherin 4, FAT-J, HKLLS2, LOC108348049, NBLA00548, RGD1564291, VMLDS2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fat4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bacterial cadherin-like domain
- Cadherin-like
- LamG
- Human growth factor-like EGF
- Bacterial Ig domain
- Cadherin repeat-like domain
- EGF domain
- protein binding
- laminin G domain
- EGF_CA
Pathways
Biological processes and signaling networks where the Fat4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- Van Maldergem syndrome type 2
- open-angle glaucoma
- hepatocellular carcinoma
- liver cancer
- Hennekam lymphangiectasia-lymphedema syndrome type 2
- major depression
- congenital anomalies of kidney and urinary tract
- myeloproliferative neoplasm
- myeloproliferative disorder
regulates
- MER-WWC1-FRMD6
role in cell
- cell viability
- migration
- proliferation
- apoptosis
- organization
- orientation
- cell-cell adhesion
- dysfunction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- apical compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fat4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heterophilic cell-cell adhesion
- hippo signaling cascade
- neurogenesis
- cerebral cortex development
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding