Fat4

Predicted to enable calcium ion binding activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; hippo signaling; and nervous system development. Acts upstream of or within several processes, including cell surface receptor signaling pathway; condensed mesenchymal cell proliferation; and ossification involved in bone maturation. Located in apical part of cell. Is expressed in several structures, including central nervous system; embryo mesenchyme; heart; hemolymphoid system gland; and metanephros. Human ortholog(s) of this gene implicated in Hennekam syndrome and Van Maldergem syndrome 2. Orthologous to human FAT4 (FAT atypical cadherin 4). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fat4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Fat4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Fat4 gene, providing context for its role in the cell.