LOC103694874 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to act upstream of or within basement membrane organization; collagen fibril organization; and negative regulation of fat cell differentiation. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Orthologous to human MMP11 (matrix metallopeptidase 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | LOC103694874 |
| Official Name | stromelysin-3 [Source:RGD Symbol;Acc:9106139] |
| Ensembl ID | ENSRNOG00000028344 |
| Bio databases IDs | |
| Aliases | stromelysin-3 |
| Synonyms | LOC103694874, matrix metallopeptidase 11, SL-3, ST3, STMY3, stromelysin 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc103694874 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- metallopeptidase
- Hemopexin-like repeats
- Matrixin
- ZnMc
- serine endopeptidase
- peptidase
- HX
- Zinc-dependent metalloprotease
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Loc103694874 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- liver cancer
- cancer
- epithelial cancer
- osteoarthritis
- salivary duct carcinoma
- salivary duct cancer
- Dupuytren contracture
- laser induced choroidal neovascularization
role in cell
- migration
- invasion by
- expression in
- growth
- proliferation
- apoptosis
- quantity
- cell viability
- differentiation
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc103694874 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extracellular matrix disassembly
- proteolysis
- negative regulation of fat cell differentiation
- extracellular matrix organization
- basement membrane organization
- collagen catabolic process
- collagen fibril organization
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix
- extracellular region
- Golgi lumen
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- serine-type endopeptidase activity
- metalloendopeptidase activity