Ccl9 Gene Summary [Rat]
Predicted to enable CCR chemokine receptor binding activity; chemoattractant activity; and chemokine activity. Involved in positive regulation of osteoclast differentiation. Predicted to be active in extracellular space. Orthologous to several human genes including CCL15 (C-C motif chemokine ligand 15). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccl9 |
| Official Name | chemokine (C-C motif) ligand 9 [Source:RGD Symbol;Acc:1310563] |
| Ensembl ID | ENSRNOG00000028548 |
| Bio databases IDs | |
| Aliases | chemokine (C-C motif) ligand 9 |
| Synonyms | CCF18, Ccl10, Ccl9/10, C-C motif chemokine ligand 9, MIP-1 gamma, MIP-1 γ, MRP-2, Scya10, Scya9 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccl9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- chemokine
- chemoattractant
- Small cytokines (intecrine/chemokine), interleukin-8 like
- cytokine
Pathways
Biological processes and signaling networks where the Ccl9 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- insulin-dependent diabetes mellitus
- metastasis
- Sjögren syndrome
- plasma cell neoplasm
- B cell cancer
- mature B-cell neoplasia
regulates
- Ca2+
- NFkB (complex)
- CCR1
role in cell
- apoptosis
- activation
- differentiation
- migration
- survival
- chemotaxis
- quantity
- internalization by
- leukemic potential
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- intracellular space