Mknk2 Gene Summary [Rat]
Predicted to enable ATP binding activity; calmodulin binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to arsenic-containing substance; intracellular signal transduction; and protein phosphorylation. Predicted to act upstream of or within extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in nuclear body. Predicted to be active in cytoplasm and nucleus. Orthologous to human MKNK2 (MAPK interacting serine/threonine kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mknk2 |
| Official Name | MAPK interacting serine/threonine kinase 2 [Source:RGD Symbol;Acc:1305728] |
| Ensembl ID | ENSRNOG00000029028 |
| Bio databases IDs | |
| Aliases | MAPK interacting serine/threonine kinase 2 |
| Synonyms | 2010016G11Rik, DKFZP434N0211, GPRK7, MAP kinase-interacting serine/threonine kinase 2, MAPK interacting serine/threonine kinase 2, Mknk2a, MNK2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mknk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein Kinases, catalytic domain
- MAPK binding site
- ATP binding
- protein binding
- Protein kinase domain
- basic domain
Pathways
Biological processes and signaling networks where the Mknk2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- cleft lip
- carpal tunnel syndrome
- tumorigenesis
role in cell
- activation in
- expression in
- growth
- phosphorylation in
- colony formation
- response by
- signal transduction in
- hematopoiesis
- suppression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mknk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- hemopoiesis
- cellular response to arsenic-containing substance
- protein autophosphorylation
- cell surface receptor signaling pathway
- extrinsic apoptotic signaling pathway in absence of ligand
- protein phosphorylation
- peptidyl-serine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- PML body
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- protein binding
- metal ion binding
- calmodulin-dependent protein kinase activity
- protein serine/threonine kinase activity
- calcium-dependent protein serine/threonine kinase activity